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In addition to behavioral responses and vocalizations, physiological parameters can be associated with pain [6]. Henke-Sass, Wolf Non-Sterile 2-Part Syringes 14817194 Print . Additional Info. Autoclavable up to 200 C (392 F). Mean SEM serum CgA concentrations (g/L) are shown for the different treatment groups. Twenty minutes before anesthetic induction, a local anesthetic cream (Emla, AstraZenecea GmbH, Wedel, Germany) was applied to the piglets ventral neck to numb the skin for the establishment of venous and arterial access. Priebe HJ, Skarvan K. Regulation of the cardiovascular system In: Nijhawan N, Warltier DC, editors. Since 2-part syringes do not have rubber gasket and silicone oil(used as lubricant in 3-part syringes), they do not contaminate the sample and can be used to handle a variety of materials, including organic solvents.HSW 2-part syringes are made of polypropylene barrel and polyethylene plunger. Baseline blood samples were taken 5 minutes after placement of the catheters. A point of criticism could be that limb movements are hard to evaluate under isoflurane anesthesia. Hug PJ, Cap VH, Honegger J, Schupbach-Regula G, Schwarz A, Bettschart-Wolfensberger R. Optimization of analgesia for piglet castration under isoflurane anaesthesia with parenteral butorphanol, meloxicam or intratesticular lidocaine. ISO certified. To measure nociception during injection and castration, a minimal anesthesia protocol was used to exclude disruptive factors such as fear and stress. VWR supports you in your autosampler vial selection process through on-site consultations with our Chromatography Specialists, and providing samples when needed. Shop 2-Part Luer Slip Syringes | Air-Tite Products All syringes (except 1 ml versions) can be supplied with luer lock tip upon request. National Library of Medicine Weve built our reputation on consistent, comprehensive mastery of day-to-day operations, allowing lab, clinical, and production environments to focus their high-value resources on core scientific priorities. * shows a more detailed overview of the time points of the measurements of BP, HR and limb movements during an event. Further, serum cortisol levels can be measured to determine castration-induced neuroendocrine stress reactions [13]. We appreciate your feedback. No significant differences were found among the groups at any time point. Fisher Scientific is always working to improve our content for you. The VWR Traceable Logger-Trac Temperature Datalogger is perfect for monitoring material during storage, handling, and transportation. Fifty-four hybrid German Landrace/German Large White x Pietrain male piglets aged 3 to 7 days (5.31.1 days) with weights above 1.4 kg (mean: 2.09 kg 0.4 kg) were included in this study. The store will not work correctly in the case when cookies are disabled. Bulk products are packed in a whole same bag. As your trusted, collaborative partner, Avantor Services helps you increase efficiency, maximize productivity, and accelerate innovation. Regarding cutting of the spermatic cord in local anesthetic groups P (p < 0.001), L (p < 0.001), B (p < 0.001) and M (p < 0.001), the deviation in the maximum MAP change was significantly decreased compared to that in the NaCl group. Handling = no injection and no castration, only simulation of the procedures; NaCl = injection of sodium chloride (NaCl) and castration; Procaine = injection of procaine 4% and castration; Lidocaine = injection of lidocaine 2% and castration; Bupivacaine = injection of bupivacaine 0.5% and castration; Mepivacaine = injection of mepivacaine 2% and castration. Local anesthetics induce anesthesia by blocking sodium channels in the peripheral nerves in the area in which they were administered. Please contact us if you have any questions. This ensured that both the movements of the four limbs and tension of the back could be perceived and assessed. This must be further discussed if intratesticular injection is to meet the requirements of the German welfare act, which requests the total elimination of pain during the surgical procedure. and transmitted securely. Bupivacaine mandibular nerve block affects intraoperative blood pressure and heart rate in a Yucatan miniature swine mandibular condylectomy model: a pilot study, Vocal responses of piglets to castration: identifying procedural sources of pain. During skin incision, the NaCl group had the highest score, with 5.6 points on average, followed by the M (0.3) and P (4.2) groups. German law also permits the application of local veterinary medicinal products that are able to eliminate pain [4]. In: Annual meeting of the European Association for animal production. Piglets from 15 litters were randomly assigned to one of the six treatment groups (n = 9 per group). VWR will support you from the latest life science products to the guaranteed purity of organic building blocks VWR is ready to support your production facility with reliable access to raw materials and essential supplies. 6976. For cortisol and chromogranin A (CgA) measurements, blood samples were collected 20 and 40 minutes after the cutting of the spermatic cord. Product Info [Sterile, Individual Packaging] Product line Pyrogen-free / PVC-free / non-toxic PP (polypropylene) barrel, PE (polyethylene) plunger 2-part single use syringe No rubber gasket and silicone oil Environmentally friendly packaging Sterile, individual blister packaging High chemical resistance Luer Slip, non-sterile, bulk, pack of 500 Related Products. To minimize this variance in applied pressure and localization, the reflex was always tested by the same two persons, and the same clamp was used. Injection itself was not associated with significant changes in MAP or HR. These gloves offer the perfect combination of improved elongation with outstanding protection from chemotherapy drugs, and an FDA-approved low dermatitis potential claim. Packaged in individual sterile poly bags. In conclusion, all four local anesthetics administered are highly effective at reducing signs of nociception during castration under light isoflurane anesthesia. VWR provides the cell culture community with access to the most reliable supply of exceptional quality Fetal Bovine Serum: VWR Life Science Seradigm. Latex-free and containing no rubber, silicone oil, styrene, BPA, or DEHP, Henke-Sass Wolfs (HSW) Norm-Ject syringes are the choice for any situation needing inert, hypo-allergenic syringes. We continue to set science in motion to create a better world by providing you with the right solutions to keep moving forward. Weight gain, behavioral and cortisol changes after orchiectomy with or without local anaesthesia in piglets. Systolic, diastolic and MAP and an electrocardiogram (ECG) were recorded continuously with appropriate hardware modules and corresponding software (PLUGSYS module, Transducer Amplifier module TAM, heart rate module, HAEMODYN software, Hugo Sachs ElektronikHarvard Apparatus GmbH, March-Hugstetten, Germany). 15 through 25 gauge are thin wall construction while 27 through 30 gauge are regular wall. Bulk products have same syringes as luer-slip syringes, but not sterilized. Blood samples for catecholamines were centrifuged (5 minutes, 3000 U/min, 4 C) immediately after collection. Find everything you need to start setting up your lab, including special savings, checklists, and more From scientific discovery to scale-up and commercial delivery, Avantor offers mission-critical products, services and solutions on a global scale. Typical sympathetic reactions that can be measured in pigs are increased blood pressure (BP) and heart rate (HR) and the secretion of catecholamines (epinephrine and norepinephrine) [8,9], and mean arterial blood pressure (MAP) is one of the most sensitive nociceptive parameters in pigs [10]. An oral bolus of iron (1 ml per piglet; URSOFERRAN 150 mg/ml, Serumwerk Bernburg AG, Bernburg, Germany) was given during the first ten hours of life. (Excluding applicable taxes and shipping), Using MicroCannulas for Canine and Feline Entropion Surgery, Best Repeater Syringe for Cattle and Other Livestock, Eliminate Injectable Waste With Low Dead Space Syringes, Dr. Runge and Air-Tite Partnered to Prevent Blindness in Ukraine Infants. Fisher Scientific - Henke-Sass, Wolf syringes feature a 2-part construction containing no rubber and eliminating the need for silicone oil. Henkeject - Sercrim Labtech - henkeject As a negative control, another group underwent simulated injection and castration (H, handling). The six bars illustrate the maximum percent change from baseline within 1 minute after injection (A, D), skin incision (B, E) and cutting of the spermatic cord (C, F) in the different experimental groups. Gonadotropin-releasing-hormone (GnRH)-vaccination, boar fattening and surgical castration under general anesthesia are discussed as alternatives to castration without anesthesia. Read more, Anesthetic dosing wheel used for intraligamental and subcutaneous injections. Contact VWR Custom Manufacturing Services at 1.800.932.5000 or VWRCustom@vwr.com. Standard programme of available HSW HENKE-JECT two-part single-use syringes without needle with by-packed needle * with ml-grading **with insulin grading All syringe sizes are available with luer slip tip as standard. [9] even observed an increase in epinephrine and norepinephrine in piglets injected with 2% procaine, and Hofmann et al. Norm-Ject syringes are latex free, and contain no rubber, silicone oil, styrene or DEHP. Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. Therefore, to measure pure nociception, light isoflurane anesthesia was administered. Easy access to products and protocols for research use only in the identification of 2019-nCoV based on Centers for Disease Control and Prevention (CDC) recommendations. Piglets breathed spontaneously, and inspiratory and expiratory isoflurane was assessed (Vamos plus, Drger Medical Deutschland GmbH, Unterhaching, Germany). For invasive BP measurement, a micro tip catheter (SPR-407 Mikro-Tip, Millar, Inc., Houston, TX, USA) was placed in the carotid artery. Air-Tite Henke-Sass Wolf Norm-Ject 2-Part Luer Slip Bulk Non-Sterile Skin at the arterial and venous access site was injected with a maximum of 0.3 ml lidocaine (lidocaine 2%, bela-pharm Arzneimittelfabrik, Vechta, Germany). Gibbs NM, Larach DR, Skeehan TM, Schuler HG. You can use the site map below to help locate the page you were looking for, or start at the home page. However, injection of a local anesthetic seems to be painful. Plasma CgA concentrations in piglets at time points before surgical castration and 20 and 40 minutes after surgery are shown in Table 4. We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Classification of Chronic Pain. We can send you the products via EMS, DHL, FedEx, UPS, etc. The four steps in the development of feeling pain are transduction, transmission, modulation and perception. Disposable syringes HSW NORM-JECT, 2-part, PP/PE, sterile-PP barrel, with PE piston . These syringes are the choice for any situation needing an inert, non-reactive syringe. All contact information provided shall also be maintained in accordance with our Castration without any pain relief provoked the highest increase in BP. FDA registered, CE Mark, ISO 9001 certified. These syringes are the choice for any situation needing an inert, non-reactive syringe. Your session has expired. Henke-Sass, Wolf Non-Sterile 2-Part Syringes | Fisher Scientific Zls S. Mglichkeiten der Schmerzreduzierung bei der Kastration mnnlicher Saugferkel. 05, ** p < 0.01, *** p < 0.001, n.s. You can select and customize services for peak efficiency, quality, and accelerated innovation. -Wipe-resistant scale -Transparent cylinder -Pyrogen-free, non-toxic and PVC-free Polyethylene (Plunger), Polypropylene (Barrel). Values shown are means SEMs. To evaluate the noxious stimulus of skin incision and the noxious stimulus of cutting the spermatic cord separately, a period of 2 minutes for stabilization of hemodynamic parameters was provided before the spermatic cord of the right and left testicle were severed using an emasculator. More Details. Henke-Sass, Wolf HSW HENKE-JECT, Disposable 2-part Syringe 50 ml Read more, HSW 2-Part syringes are latex free, and contain no rubber, silicone oil, styrene or DEHP. Then, 0.5 ml of a local anesthetic or NaCl was injected intratesticularly (i.t. 05. Kluivers-Poodt M, Houx BB, Robben SR, Koop G, Lambooij E, Hellebrekers LJ. The optimization of the injection technique and the verification of whether the same analgesic effects can be achieved by these methods are part of further studies. VWR's cell culture portfolio provides all the essential instruments, tailored to the needs of your cell biology processes. Minimum alveolar concentration of I-653 and isoflurane in pigs: definition of a supramaximal stimulus. Quanta Biosciences and VWR are proud to fund a grant award for publication of research involving qPCR methodologies utilizing any Quanta Bioscience qPCR reagent in JoVE. Regarding the analysis of stress hormones after castration after the administration of local anesthesia, the results of previous studies are inconclusive. Nociception mainly refers to the first three components, lacking the conscious awareness and emotional component but including all vegetative, glycemic stress responses and motoric reflex responses, respectively. HSW HENKE-JECT - three-part | HenkeSassWolf Values shown are means SEMs. Differentiating pain from emotions such as fear or anger is challenging in a conscious piglet. Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Syringe Needles and Accessories, Lab Coats, Aprons, and Other Safety Apparel, Sharps Disposal Containers and Accessories, Classroom Laboratory Supplies and Consumables, Applied Biosystems TaqMan Assay and Arrays Search Tool, Applied Biosystems TaqMan Custom Assay Design Tools, Applied Biosystems Custom qPCR Primers and TaqMan Probes Tool, missing translation for 'viewProductCertificates', Chemical Storage and Management Resource Center. Baseline values for all parameters were taken five minutes after placement of the catheters and prior to the first toe pinch reflex test. A decrease in BP did not necessarily represent a decrease in HR in the same piglet. Rittershaus D. Topische ansthesieverfahren zur schmerzreduktion bei der saugferkelkastration. Product Code. As pain-related physiological responses are easily influenced by stress and fear, it is difficult to discriminate pain from handling stress [7]. Luer-slip syringe requires just manual pushing of the needle into the tip. This was the highest value observed during skin incision and was also significantly different from that in the H group (p < 0.001). Courboulay V, Hemonic A, Gadonna M, Prunier A. Castration under analgesia or local anesthesia: impact on pain and labour demand. For the best experience on our site, be sure to turn on Javascript in your browser. Be aware that Internet Explorer is not fully supported on our website. A limitation of the present study is that nociception is only assessed on the basis of acute cardiovascular and humoral responses and limb movements. The L, B and M groups did not move at all (Fig 3). Oxygen saturation and HR were measured via a pulse oximeter (2500A VET, Nonin Medical Inc., Plymouth, MN, USA) placed at the base of the piglets tail. The mean standard error of the mean (SEM) body weights of the piglets in each treatment group were as follows: H: 2.2 0.5; NaCl: 2.1 0.6; P: 1.8 0.3; L: 2.5 0.5; B: 2.1 0.4; and M: 2.2 0.4 kg. Product Certificates, ErrorBody: {errorBody=No ResponseBody, fulfilledBy=[fishersci-products-ui:fishersci-products-ui-5cb56866f6-h8vpd], responseTime={fishersci-products-ui=0ms}}, Electrophoresis, Western Blotting and ELISA, Chromatography and Mass Spectrometry Reagents, Laboratory Medicine - Pathology, Core Lab, Microbiology, Blood, Hematology, and Coagulation Testing, Urine Testing Reagents, Controls, and Strips, POC Diagnostic Instruments and Accessories, Microbiological Media and Media Additives, Microbiological Specimen Transport and Collection, Chlorine and pH Test Kits and Test Strips, Chemical Storage and Management Resource Center. Buy Henke-Sass, Wolf HSW HENKE-JECT, Disposable 2-part Syringe 50 ml 4850031000 with Free Delivery available (Terms and Conditions apply) . All syringes (except 1 ml versions) can be supplied with luer lock tip upon request. Exclusive utilization of thoroughly tested, chemically stable materials from leading European manufacturers ensure uncomplicated application across the entire therapeutic spectrum. Henke-Sass, Wolf Non-Sterile 2-Part Syringes - Fisher Sci An overview of the experimental setup is shown in Fig 1. [39] did not find a reduced cortisol response after castration with the administration of local anesthetics compared to piglets castrated without anesthesia. Read more, HSW 2-Part Luer Slip Laboratory Convenience Packs, HSW 2-Part Luer Lock Laboratory Convenience Packs. No significant differences were found between groups regarding parameters of plasma cortisol, catecholamines and CgA. This was a randomized and double-blinded experimental study. During injection, no significant difference among the groups was detected. Vienna, R Foundation for Statistical Computing; 2017. The distribution of all continuous parameters was tested using the Shapiro-Wilk normality test. Please sign in to view account pricing and product availability. By excluding stress and fear as disruptive factors via a minimum anesthesia model, all piglets received individual minimum alveolar concentration (MAC) isoflurane anesthesia. Therefore, according to the German Animal Welfare Act, surgical castration of male piglets less than seven days of age without anesthesia will be forbidden in 2021 [4]. Supplier: Henke-Sass, Wolf AB10LL View more versions of this product Catalog No. Systematic review and meta-analysis of the effect of warming local anesthetics on injection pain. Luer-lock syringe requires to twist a needle (or syringe filter) onto the tip, so that it becomes locked and sealed. In addition, each event was filmed and evaluated. No significant differences were found in norepinephrine measurements. Serum samples for cortisol and CgA were taken 20 and 40 minutes after castration (cutting of the spermatic cord). Quick View! Statistical significance is indicated by * p 0.05, ** p < 0.01, *** p < 0.001; n.s. Nothing that happens in the labor other workplace is as important as your health and safety. 1ml syringes are LDS syringes. [20] and Hug et al. Copyright Midland Scientific Inc. All Rights Reserved 2020. In this way, physiological reactions could be directly associated with nociception during castration. 1.8 ml each sample) were taken via the venous port at the following time points. Featured Solutions Medical Lab Supplies & Equipment Air-Tite Syringe & Needle Products HSW Norm-Ject syringes HSW Norm-Ject syringes Latex-free and containing no rubber, silicone oil, styrene, BPA, or DEHP, Henke-Sass Wolf's (HSW) Norm-Ject syringes are the choice for any situation needing inert, hypo-allergenic syringes. The all-plastic syringe with a Luer slip. As our customers needs have evolved, so have our capabilities. A single reaction to the toe pinch, in the form of a slight withdrawal of the hind limb, was evaluated as appropriate anesthetic depth. Injection into the testis and castration did not cause significant changes in the stress hormone concentrations of cortisol, CgA, epinephrine or norepinephrine in the experimental groups. Long-term weight gain and economic impact in pigs castrated under local anaesthesia. henkeject@sercrim.comW. We set science in motion to create a better world. This work was funded by the German Federal Ministry of Food and Agriculture (BMEL, https://www.bmel.de) based on a decision of the Parliament of the Federal Republic of Germany, granted by the Federal Office for Agriculture and Food (BLE, https://www.ble.de; grant number: 2817HS016, 2817HS013). An official website of the United States government. The results confirm that castration without analgesia is highly painful. Inclusion in an NLM database does not imply endorsement of, or agreement with, Zankl A, Ritzmann M, Zols S, Heinritzi K. The efficacy of local anaesthetics administered prior to castration of male suckling piglets. The score was applied to analyze the intensity of limb movements: handling = neither injection nor castration, only simulation of the procedures; NaCl = castration without preoperative analgesia; procaine, lidocaine, bupivacaine, and mepivacaine = castration under preoperative local anesthetic. Acute physiological responses to castration-related pain in piglets: the effect of two local anesthetics with or without meloxicam, More than three movements, long-lasting movements. Twenty minutes before castration, all treatment groups except group H received one injection per testis. After the spermatic cord was cut, the NaCl group reached a score of 8.4, and the P group had a score of 0.2. R Development Core Team. All rights reserved. An automatic self-filling 1-ml syringe (HSW ECO-MATIC , Henke-Sass, Wolf GmbH, Tuttlingen, Germany) with a 25G cannula (0.5x16 mm, B. Braun TravaCare GmbH, Hallbergmoos, Germany) was used for injection. Henke-Sass, Wolf GmbH has sold the Norm-Ject brand to B.Braun Melsungen AG.The Norm-Ject brand continues to be manufactured to the same standards and specifications, and in the same factory in Germany as before. These As a library, NLM provides access to scientific literature. Cleanrooms and controlled environments are used for ultraclean conditions in research and manufacturing. If you dont need sterile product, you can choose bulk products. Effect of the number of incisions and use of local anesthesia on the physiological indicators of surgically-castrated piglets. These unique plastic syringes are more chemically resistant than rubber-tipped syringes and have a positive safety stop to help prevent accidental spills. The only difference in group H was that injection and castration were only simulated. Bova JF, da Cunha AF, Stout RW, Bhumiratana S, Alfi DM, Eisig SB, et al. Here you can find all information as PDF for download. All syringes (except 1 ml versions) can be supplied with luer lock tip upon request. Exclusive utilization of thoroughly tested, chemically stable materials from leading European manufacturers ensure uncomplicated application across the entire therapeutic spectrum. Avantor carries a broad range of trusted products to help you meet the needs of your lab applications and protocols. Isoflurane anesthesia and preparations and measurements (blood parameters, BP, HR, movements, etc.) [16], who found that the lidocaine groups produced significantly decreased scores in vocalization and defensive movements. An explanation for the failure of blood hormones to illustrate the nociception experienced by the piglets in our model may be that the procedures were performed under isoflurane anesthesia. This suggests that in addition to the injection itself, the pH of the applied solution plays a role as a pain trigger. We use operational excellence to deliver solutions that enable research, testing, production, and commercialization across the globe. HSW ECO-MATIC with Bottle Mount Universal Collars, HSW HENKE-JECT Insulin syringes 0.5 ml / 1 ml. [60]. = no significance. Assortment of popular, everyday Nalgene labware in a convenient pack. Anesthetic depth defined using multiple noxious stimuli during isoflurane/oxygen anesthesia. Sercrim Labtech Co,, Ltd795-6, Bugaksan-ro, Seongbuk-gu, Seoul, Republic of KoreaT:+82-2-911-4114E. Made from polypropylene and polyethylene. Through channel binding, sodium influx into neurons is inhibited, and no action potential is formed [14]. 795-6, Bugaksan-ro, Seongbuk-gu, Seoul, Republic of Korea8-12, Dongsomun-ro 23-gil, Seongbuk-gu, Seoul, Republic of Korea, HSW HENKE-JECT 2-part 5 ML (6 ML) ECCENTRIC, HSW HENKE-JECT 2-part 5 ML (6 ML) CENTRIC, HSW HENKE-JECT 2-part 2 ML (3 ML) MINI-BULK, HSW HENKE-JECT 2-part 5 ML (6 ML) MINI-BULK, HSW HENKE-JECT 2-part 10 ML (12 ML) MINI-BULK, HSW HENKE-JECT 2-part 20 ML (24 ML) MINI-BULK, Recommended by Chromatography Institute of America, Pyrogen-free, PVC-free, Non-toxic, No-rubber, No-silicone oil, Can be used in HPLC, biology, medical, chemical industries, Henke-Sass, Wolf is the leading manufacturer in the field of medical endoscopy, veterinary products as well as human and dental syringes, In Asia, Henke-Ject is distributed by Sercrim, PP(polypropylene) barrel, PE(polyethylene) plunger, Used in HPLC, biology, medical, chemical industries. Don't miss out, order yours today! Microsoft is no longer supporting it, and to secure our site we have chosen not to fully support it. These unique plastic syringes are more chemically resistant than rubber-tipped syringes and have a positive safety stop to help prevent accidental spills.These HSW 2-Part syringes packaged BULK, NON-STERILE. Autoclavable up to 200 C (392 F). and subscrotal injections showed clear limb movement responses. Animal welfare implications of surgical castration and its alternatives in pigs. We will not share your information for any other purposes. This item has been discontinued by the manufacturer and is no longer available. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Get it as soon as Wednesday, May 31. . The deviation from baseline in the NaCl group was 24%. Mean SEM plasma epinephrine and norepinephrine concentrations (g/L) are shown for the different treatment groups. Price: 11.22. In a study by Kluivers-Poodt et al. A statistically significant change from baseline is indicated by * p 0. HSW Norm-Ject Sterile Luer-Lock Syringes - IVF Store All contact information provided shall also be maintained in accordance with our 2-Part Syringe Information Sheet Henke-Ject Product Specification Sheet Chromatography Institute of America Norm-Ject Chemical Resistance Chart Inner Diameter HSW Syringes NORM-JECT and Henke-Ject syringes are latex free, and contain no rubber, silicone oil, styrene or DEHP. Values shown are means SEMs. It cannot be fully excluded that in some animals, anesthesia might have blocked some reactions; in the NaCl group, only six out of nine piglets exhibited limb movements. Surgical castration without pain relief revealed significant changes in mean arterial blood pressure (MAP) and HR. Our product offerings can help with biomedical research, forensic work, and clinical diagnostics. In this study, it was assumed that all piglets experienced similar stress from the induction procedure and the establishment of the measurements. Aside from one piglet in the P group, no limb movements were detected in piglets in the other experimental groups.